Director of the Centre de Recherche des Cordeliers, Inserm
Since 2019
Sorbonne Université, Université de Paris
Professor of Medicine, Oncology
Since 2009
University Paris Descartes/Hopital Européen Georges Pompidou, AP-HP
Head of the «Functional genomic of solid tumors» Team
Since 2007
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Education
Post-doctoral Fellow in Genetic-Oncology
1994 to 1996
Institut Curie
PhD in life science, Fundamental Basis of Oncogenesis
1994
University Paris 7
Specialization in Internal Medicine
1994
AIHP
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Pubmed
New insights in the management of Hepatocellular Adenoma.
2020
Liver international : official journal of the International Association for the Study of the Liver
Read it here
Clinical Impact of Genomic Diversity From Early to Advanced Hepatocellular Carcinoma.
2020
Hepatology (Baltimore, Md.)
Read it here
Corrigendum to: "BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA" [J Hepatol (2020) 1-13].
HCC Summit, EASL, Geneva 2018Co-organizerCold Spring Harbor Asia liver metabolism and cancer, Suzhou (2016)Co-organizerConférence européenne monothématique «Basic research in HCC» EASL, Geneva, 2014Co-organizer
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Honors
Docteur Honoris Causa Université Catholique de Louvain
2019
Chevalier de la Légion d’honneur
2018
Prix René et André Duquesne
2018
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Get updatedReceive the latest news from Prof. Jessica Zucman-Rossi
Work ExperienceDirector of the Centre de Recherche des Cordeliers, Inserm
Since 2019
Sorbonne Université, Université de Paris
Professor of Medicine, Oncology
Since 2009
University Paris Descartes/Hopital Européen Georges Pompidou, AP-HP
Head of the «Functional genomic of solid tumors» Team
Since 2007
Co-editor Journal of Hepatology, EIC JHEP Reports
2014 to 2019
Executive secretary of the International Liver Cancer Association (ILCA)
2015 to 2019
EducationPost-doctoral Fellow in Genetic-Oncology
1994 to 1996
Institut Curie
PhD in life science, Fundamental Basis of Oncogenesis
1994
University Paris 7
Specialization in Internal Medicine
1994
AIHP
MD
1990
University Paris 7, France
PubmedNew insights in the management of Hepatocellular Adenoma.
2020
Liver international : official journal of the International Association for the Study of the Liver
Read it here
Clinical Impact of Genomic Diversity From Early to Advanced Hepatocellular Carcinoma.
2020
Hepatology (Baltimore, Md.)
Read it here
Corrigendum to: "BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA" [J Hepatol (2020) 1-13].
2020
Journal of hepatology
Read it here
Long-term Evolution of Hepatocellular Adenomas at MRI Follow-up.
2020
Radiology
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Genetic alterations of malignant pleural mesothelioma: association with tumor heterogeneity and overall survival.
2020
Molecular oncology
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Recurrent chromosomal rearrangements of <i>ROS1</i>, <i>FRK</i> and <i>IL6</i> activating JAK/STAT pathway in inflammatory hepatocellular adenomas.
2020
Gut
Read it here
BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA.
2020
Journal of hepatology
Read it here
<i>RSPO2</i> abnormal transcripts result from read-through in liver tumours with high ß-catenin activation and <i>CTNNB1</i> mutations.
2020
Gut
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Polyploidy spectrum: a new marker in HCC classification.
2020
Gut
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Adeno-associated virus in the liver: natural history and consequences in tumour development.
2020
Gut
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Genetics of HCC: Novel approaches to explore molecular diversity.
2020
Hepatology (Baltimore, Md.)
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A 17-Beta-Hydroxysteroid Dehydrogenase 13 Variant Protects From Hepatocellular Carcinoma Development in Alcoholic Liver Disease.
2019
Hepatology (Baltimore, Md.)
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Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications.
2019
Nature communications
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Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations.
2019
Cell metabolism
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PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases.
2019
International journal of cancer
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Fibroblast Growth Factor Receptor-2 Polymorphism rs2981582 is Correlated With Progression-free Survival and Overall Survival in Patients With Metastatic Clear-cell Renal Cell Carcinoma Treated With Sunitinib.
2019
Clinical genitourinary cancer
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Genomic Medicine and Implications for Hepatocellular Carcinoma Prevention and Therapy.
2019
Gastroenterology
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Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma.
2019
Journal of hepatology
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Lect2 Controls Inflammatory Monocytes to Constrain the Growth and Progression of Hepatocellular Carcinoma.
2019
Hepatology (Baltimore, Md.)
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Dual Targeting of Histone Methyltransferase G9a and DNA-Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma.
2019
Hepatology (Baltimore, Md.)
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Dynamics and predicted drug response of a gene network linking dedifferentiation with beta-catenin dysfunction in hepatocellular carcinoma.
2019
Journal of hepatology
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Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response.
2019
Gastroenterology
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Journal of Hepatology: The Home of Liver Research, 2015-2019.
2019
Journal of hepatology
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Hepatocellular Carcinomas With Mutational Activation of Beta-Catenin Require Choline and Can Be Detected by Positron Emission Tomography.
2019
Gastroenterology
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Molecular and histological correlations in liver cancer.
2019
Journal of hepatology
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Clear-cell Renal Cell Carcinoma: Molecular Characterization of IMDC Risk Groups and Sarcomatoid Tumors.
2019
Clinical genitourinary cancer
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The role of telomeres and telomerase in cirrhosis and liver cancer.
2019
Nature reviews. Gastroenterology & hepatology
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ESM1 as a Marker of Macrotrabecular-Massive Hepatocellular Carcinoma.
2019
Clinical cancer research : an official journal of the American Association for Cancer Research
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Immunogenomics of Metastatic Clear-Cell Renal Cell Carcinoma: Remarkable Response to Nivolumab in a Patient With a Pathogenic Germ Line BRCA1 Mutation.
2019
Clinical genitourinary cancer
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<i>APC</i> germline hepatoblastomas demonstrate cisplatin-induced intratumor tertiary lymphoid structures.
2019
Oncoimmunology
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Natural history of liver adenomatosis: A long-term observational study.
2019
Journal of hepatology
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JHEP Reports: A new EASL open access journal.
2019
JHEP reports : innovation in hepatology
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Compliance With Hepatocellular Carcinoma Surveillance Guidelines Associated With Increased Lead-Time Adjusted Survival of Patients With Compensated Viral Cirrhosis: A Multi-Center Cohort Study.
2018
Gastroenterology
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AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation.
2018
Journal of hepatology
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cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation.
2018
Hepatology (Baltimore, Md.)
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Polymorphisms in the Von Hippel-Lindau Gene Are Associated With Overall Survival in Metastatic Clear-Cell Renal-Cell Carcinoma Patients Treated With VEGFR Tyrosine Kinase Inhibitors.
2018
Clinical genitourinary cancer
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Molecular Subtypes of Clear-cell Renal Cell Carcinoma are Prognostic for Outcome After Complete Metastasectomy.
2018
European urology
Read it here
From the Editor's desk...: March 2018.
2018
Journal of hepatology
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Pro-angiogenic gene expression is associated with better outcome on sunitinib in metastatic clear-cell renal cell carcinoma.
2018
Acta oncologica (Stockholm, Sweden)
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Argininosuccinate synthase 1 and periportal gene expression in sonic hedgehog hepatocellular adenomas.
2018
Hepatology (Baltimore, Md.)
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Molecular Subtypes of Clear Cell Renal Cell Carcinoma Are Associated With Outcome During Pazopanib Therapy in the Metastatic Setting.
2018
Clinical genitourinary cancer
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Palimpsest: an R package for studying mutational and structural variant signatures along clonal evolution in cancer.
2018
Bioinformatics (Oxford, England)
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Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling.
2018
Cancer cell
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microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis.
2018
Gastroenterology
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From the Editor's desk....: September 2018.
2018
Journal of hepatology
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Dietary exacerbation of metabolic stress leads to accelerated hepatic carcinogenesis in glycogen storage disease type Ia.
2018
Journal of hepatology
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Systemic AA Amyloidosis Caused by Inflammatory Hepatocellular Adenoma.
2018
The New England journal of medicine
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Assessment of signaling pathway inhibitors and identification of predictive biomarkers in malignant pleural mesothelioma.
2018
Lung cancer (Amsterdam, Netherlands)
Read it here
Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress.
2018
Nature communications
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The clinical implications of G1-G6 transcriptomic signature and 5-gene score in Korean patients with hepatocellular carcinoma.
2018
BMC cancer
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RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer.
2017
Cancer cell
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From the Editor's desk...: March 2017.
2017
Journal of hepatology
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Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas.
2017
The Journal of pathology
Read it here
From the Editor's desk.....: February 2017.
2017
Journal of hepatology
Read it here
From the Editor's desk...
2017
Journal of hepatology
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Germline and somatic DICER1 mutations in familial and sporadic liver tumors.
2017
Journal of hepatology
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Co-occurring Mutations of Tumor Suppressor Genes, <i>LATS2</i> and <i>NF2</i>, in Malignant Pleural Mesothelioma.
2017
Clinical cancer research : an official journal of the American Association for Cancer Research
Read it here
From the Editor's desk....: April 2017.
2017
Journal of hepatology
Read it here
Malignant transformation of a β-catenin inflammatory adenoma due to an S45 β-catenin-activating mutation present 12 years before.
2017
Human pathology
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Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.
2017
Gastroenterology
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Proliferation Markers Are Associated with MET Expression in Hepatocellular Carcinoma and Predict Tivantinib Sensitivity <i>In Vitro</i>.
2017
Clinical cancer research : an official journal of the American Association for Cancer Research
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Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin.
2017
Oncotarget
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Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription.
2017
The Journal of clinical investigation
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From the Editor's desk...: October 2017.
2017
Journal of hepatology
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Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification.
2017
Journal of hepatology
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aCNViewer: Comprehensive genome-wide visualization of absolute copy number and copy neutral variations.
2017
PloS one
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Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis.
Hepatology (Baltimore, Md.)
Read it here
From the Editor's desk...: December 2017.
2017
Journal of hepatology
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Note of caution: Contaminations of hepatocellular cell lines.
2017
Journal of hepatology
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Molecular classification of hepatocellular adenoma in clinical practice.
2017
Journal of hepatology
Read it here
From the Editor's desk...: May 2017.
2017
Journal of hepatology
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Focal β-catenin mutation identified on formalin-fixed and paraffin-embedded inflammatory hepatocellular adenomas.
2017
Histopathology
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A phosphokinome-based screen uncovers new drug synergies for cancer driven by liver-specific gain of nononcogenic receptor tyrosine kinases.
2017
Hepatology (Baltimore, Md.)
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Keratin 23 is a stress-inducible marker of mouse and human ductular reaction in liver disease.
2016
Journal of hepatology
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TERT promoter mutations in primary liver tumors.
2016
Clinics and research in hepatology and gastroenterology
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Inflammatory hepatocellular adenomas developed in the setting of chronic liver disease and cirrhosis.
2016
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
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Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers.
2016
Advances in immunology
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AAV2 and Hepatocellular Carcinoma.
2016
Human gene therapy
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PNPLA3 gene in liver diseases.
2016
Journal of hepatology
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Hepatocellular adenoma with malignant transformation in a patient with neonatal portal vein thrombosis.
2016
Hepatology (Baltimore, Md.)
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Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV.
2016
Molecular therapy : the journal of the American Society of Gene Therapy
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Mechanisms of HBV-induced hepatocellular carcinoma.
2016
Journal of hepatology
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Adeno-associated virus type 2 as an oncogenic virus in human hepatocellular carcinoma.
2016
Molecular & cellular oncology
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Hepatocellular carcinoma.
2016
Nature reviews. Disease primers
Read it here
Genotype-phenotype correlation of CTNNB1 mutations reveals different ß-catenin activity associated with liver tumor progression.
2016
Hepatology (Baltimore, Md.)
Read it here
From the Editor's desk...: June 2016.
2016
Journal of hepatology
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A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.
2016
Nature medicine
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Validation of VEGFR1 rs9582036 as predictive biomarker in metastatic clear-cell renal cell carcinoma patients treated with sunitinib.
2016
BJU international
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Translating the molecular diversity of hepatocellular carcinoma into clinical practice.
2016
Molecular & cellular oncology
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TGF-β1 promotes linear invadosome formation in hepatocellular carcinoma cells, through DDR1 up-regulation and collagen I cross-linking.
2016
European journal of cell biology
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Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point-mutant β-catenin.
2016
Hepatology (Baltimore, Md.)
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The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry.
2016
Hepatology (Baltimore, Md.)
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The transcriptomic G1-G6 signature of hepatocellular carcinoma in an Asian population: Association of G3 with microvascular invasion.
2016
Medicine
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Prognostic and theranostic impact of molecular subtypes and immune classifications in renal cell cancer (RCC) and colorectal cancer (CRC).
2015
Oncoimmunology
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RANK/OPG ratio of expression in primary clear-cell renal cell carcinoma is associated with bone metastasis and prognosis in patients treated with anti-VEGFR-TKIs.
2015
British journal of cancer
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Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas.
2015
Nature genetics
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Toward understanding and exploiting tumor heterogeneity.
2015
Nature medicine
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Mutations leading to constitutive active gp130/JAK1/STAT3 pathway.
Professional AssociationsHCC Summit, EASL, Geneva 2018Co-organizerCold Spring Harbor Asia liver metabolism and cancer, Suzhou (2016)Co-organizerConférence européenne monothématique «Basic research in HCC» EASL, Geneva, 2014Co-organizerSymposium « Liver tumors » à l’AACR, Washington, 2013, du FASEB liverCo-organizer
HonorsDocteur Honoris Causa Université Catholique de Louvain
2019
Chevalier de la Légion d’honneur
2018
Prix René et André Duquesne
2018
Prix « Coups d’élan » Fondation Schueller-Bettencourt
2016
Prix Raymond Rosen, Fondation pour la Recherche Médicale
2016
Prix Charles Oberling
2015
Elected fellow of the European Academy of Cancer Sciences
2014
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