Prof. Jessica Zucman-Rossi

Work Experience Director of the Centre de Recherche des Cordeliers, Inserm Professor of Medicine, Oncology Head of the «Functional genomic of solid tumors» Team Co-editor Journal of Hepatology, EIC JHEP Reports Executive secretary of the International Liver Cancer Association (ILCA)

Education Post-doctoral Fellow in Genetic-Oncology PhD in life science, Fundamental Basis of Oncogenesis Specialization in Internal Medicine MD

Pubmed New insights in the management of Hepatocellular Adenoma. Liver international : official journal of the International Association for the Study of the Liver Read it here Clinical Impact of Genomic Diversity From Early to Advanced Hepatocellular Carcinoma. Hepatology (Baltimore, Md.) Read it here Corrigendum to: "BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA" [J Hepatol (2020) 1-13]. Journal of hepatology Read it here Long-term Evolution of Hepatocellular Adenomas at MRI Follow-up. Radiology Read it here Genetic alterations of malignant pleural mesothelioma: association with tumor heterogeneity and overall survival. Molecular oncology Read it here Recurrent chromosomal rearrangements of <i>ROS1</i>, <i>FRK</i> and <i>IL6</i> activating JAK/STAT pathway in inflammatory hepatocellular adenomas. Gut Read it here BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA. Journal of hepatology Read it here <i>RSPO2</i> abnormal transcripts result from read-through in liver tumours with high ß-catenin activation and <i>CTNNB1</i> mutations. Gut Read it here Polyploidy spectrum: a new marker in HCC classification. Gut Read it here Adeno-associated virus in the liver: natural history and consequences in tumour development. Gut Read it here Genetics of HCC: Novel approaches to explore molecular diversity. Hepatology (Baltimore, Md.) Read it here A 17-Beta-Hydroxysteroid Dehydrogenase 13 Variant Protects From Hepatocellular Carcinoma Development in Alcoholic Liver Disease. Hepatology (Baltimore, Md.) Read it here Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications. Nature communications Read it here Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations. Cell metabolism Read it here PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases. International journal of cancer Read it here Fibroblast Growth Factor Receptor-2 Polymorphism rs2981582 is Correlated With Progression-free Survival and Overall Survival in Patients With Metastatic Clear-cell Renal Cell Carcinoma Treated With Sunitinib. Clinical genitourinary cancer Read it here Genomic Medicine and Implications for Hepatocellular Carcinoma Prevention and Therapy. Gastroenterology Read it here Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma. Journal of hepatology Read it here Lect2 Controls Inflammatory Monocytes to Constrain the Growth and Progression of Hepatocellular Carcinoma. Hepatology (Baltimore, Md.) Read it here Dual Targeting of Histone Methyltransferase G9a and DNA-Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma. Hepatology (Baltimore, Md.) Read it here Dynamics and predicted drug response of a gene network linking dedifferentiation with beta-catenin dysfunction in hepatocellular carcinoma. Journal of hepatology Read it here Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response. Gastroenterology Read it here Journal of Hepatology: The Home of Liver Research, 2015-2019. Journal of hepatology Read it here Hepatocellular Carcinomas With Mutational Activation of Beta-Catenin Require Choline and Can Be Detected by Positron Emission Tomography. Gastroenterology Read it here Molecular and histological correlations in liver cancer. Journal of hepatology Read it here Clear-cell Renal Cell Carcinoma: Molecular Characterization of IMDC Risk Groups and Sarcomatoid Tumors. Clinical genitourinary cancer Read it here The role of telomeres and telomerase in cirrhosis and liver cancer. Nature reviews. Gastroenterology & hepatology Read it here ESM1 as a Marker of Macrotrabecular-Massive Hepatocellular Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research Read it here Immunogenomics of Metastatic Clear-Cell Renal Cell Carcinoma: Remarkable Response to Nivolumab in a Patient With a Pathogenic Germ Line BRCA1 Mutation. Clinical genitourinary cancer Read it here <i>APC</i> germline hepatoblastomas demonstrate cisplatin-induced intratumor tertiary lymphoid structures. Oncoimmunology Read it here Natural history of liver adenomatosis: A long-term observational study. Journal of hepatology Read it here JHEP Reports: A new EASL open access journal. JHEP reports : innovation in hepatology Read it here Compliance With Hepatocellular Carcinoma Surveillance Guidelines Associated With Increased Lead-Time Adjusted Survival of Patients With Compensated Viral Cirrhosis: A Multi-Center Cohort Study. Gastroenterology Read it here AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation. Journal of hepatology Read it here cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation. Hepatology (Baltimore, Md.) Read it here Polymorphisms in the Von Hippel-Lindau Gene Are Associated With Overall Survival in Metastatic Clear-Cell Renal-Cell Carcinoma Patients Treated With VEGFR Tyrosine Kinase Inhibitors. Clinical genitourinary cancer Read it here Molecular Subtypes of Clear-cell Renal Cell Carcinoma are Prognostic for Outcome After Complete Metastasectomy. European urology Read it here From the Editor's desk...: March 2018. Journal of hepatology Read it here Pro-angiogenic gene expression is associated with better outcome on sunitinib in metastatic clear-cell renal cell carcinoma. Acta oncologica (Stockholm, Sweden) Read it here Argininosuccinate synthase 1 and periportal gene expression in sonic hedgehog hepatocellular adenomas. Hepatology (Baltimore, Md.) Read it here Molecular Subtypes of Clear Cell Renal Cell Carcinoma Are Associated With Outcome During Pazopanib Therapy in the Metastatic Setting. Clinical genitourinary cancer Read it here Palimpsest: an R package for studying mutational and structural variant signatures along clonal evolution in cancer. Bioinformatics (Oxford, England) Read it here Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer cell Read it here microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis. Gastroenterology Read it here From the Editor's desk....: September 2018. Journal of hepatology Read it here Dietary exacerbation of metabolic stress leads to accelerated hepatic carcinogenesis in glycogen storage disease type Ia. Journal of hepatology Read it here Systemic AA Amyloidosis Caused by Inflammatory Hepatocellular Adenoma. The New England journal of medicine Read it here Assessment of signaling pathway inhibitors and identification of predictive biomarkers in malignant pleural mesothelioma. Lung cancer (Amsterdam, Netherlands) Read it here Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress. Nature communications Read it here The clinical implications of G1-G6 transcriptomic signature and 5-gene score in Korean patients with hepatocellular carcinoma. BMC cancer Read it here RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer. Cancer cell Read it here From the Editor's desk...: March 2017. Journal of hepatology Read it here Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas. The Journal of pathology Read it here From the Editor's desk.....: February 2017. Journal of hepatology Read it here From the Editor's desk... Journal of hepatology Read it here Germline and somatic DICER1 mutations in familial and sporadic liver tumors. Journal of hepatology Read it here Co-occurring Mutations of Tumor Suppressor Genes, <i>LATS2</i> and <i>NF2</i>, in Malignant Pleural Mesothelioma. Clinical cancer research : an official journal of the American Association for Cancer Research Read it here From the Editor's desk....: April 2017. Journal of hepatology Read it here Malignant transformation of a β-catenin inflammatory adenoma due to an S45 β-catenin-activating mutation present 12 years before. Human pathology Read it here Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation. Gastroenterology Read it here Proliferation Markers Are Associated with MET Expression in Hepatocellular Carcinoma and Predict Tivantinib Sensitivity <i>In Vitro</i>. Clinical cancer research : an official journal of the American Association for Cancer Research Read it here Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin. Oncotarget Read it here Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription. The Journal of clinical investigation Read it here From the Editor's desk...: October 2017. Journal of hepatology Read it here Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification. Journal of hepatology Read it here aCNViewer: Comprehensive genome-wide visualization of absolute copy number and copy neutral variations. PloS one Read it here Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis. Nature communications Read it here Reply. Hepatology (Baltimore, Md.) Read it here From the Editor's desk...: December 2017. Journal of hepatology Read it here Note of caution: Contaminations of hepatocellular cell lines. Journal of hepatology Read it here Molecular classification of hepatocellular adenoma in clinical practice. Journal of hepatology Read it here From the Editor's desk...: May 2017. Journal of hepatology Read it here Focal β-catenin mutation identified on formalin-fixed and paraffin-embedded inflammatory hepatocellular adenomas. Histopathology Read it here A phosphokinome-based screen uncovers new drug synergies for cancer driven by liver-specific gain of nononcogenic receptor tyrosine kinases. Hepatology (Baltimore, Md.) Read it here Keratin 23 is a stress-inducible marker of mouse and human ductular reaction in liver disease. Journal of hepatology Read it here TERT promoter mutations in primary liver tumors. Clinics and research in hepatology and gastroenterology Read it here Inflammatory hepatocellular adenomas developed in the setting of chronic liver disease and cirrhosis. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Read it here Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers. Advances in immunology Read it here AAV2 and Hepatocellular Carcinoma. Human gene therapy Read it here PNPLA3 gene in liver diseases. Journal of hepatology Read it here Hepatocellular adenoma with malignant transformation in a patient with neonatal portal vein thrombosis. Hepatology (Baltimore, Md.) Read it here Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV. Molecular therapy : the journal of the American Society of Gene Therapy Read it here Mechanisms of HBV-induced hepatocellular carcinoma. Journal of hepatology Read it here Adeno-associated virus type 2 as an oncogenic virus in human hepatocellular carcinoma. Molecular & cellular oncology Read it here Hepatocellular carcinoma. Nature reviews. Disease primers Read it here Genotype-phenotype correlation of CTNNB1 mutations reveals different ß-catenin activity associated with liver tumor progression. Hepatology (Baltimore, Md.) Read it here From the Editor's desk...: June 2016. Journal of hepatology Read it here A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer. Nature medicine Read it here Validation of VEGFR1 rs9582036 as predictive biomarker in metastatic clear-cell renal cell carcinoma patients treated with sunitinib. BJU international Read it here Translating the molecular diversity of hepatocellular carcinoma into clinical practice. Molecular & cellular oncology Read it here TGF-β1 promotes linear invadosome formation in hepatocellular carcinoma cells, through DDR1 up-regulation and collagen I cross-linking. European journal of cell biology Read it here Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point-mutant β-catenin. Hepatology (Baltimore, Md.) Read it here The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry. Hepatology (Baltimore, Md.) Read it here The transcriptomic G1-G6 signature of hepatocellular carcinoma in an Asian population: Association of G3 with microvascular invasion. Medicine Read it here Prognostic and theranostic impact of molecular subtypes and immune classifications in renal cell cancer (RCC) and colorectal cancer (CRC). Oncoimmunology Read it here RANK/OPG ratio of expression in primary clear-cell renal cell carcinoma is associated with bone metastasis and prognosis in patients treated with anti-VEGFR-TKIs. British journal of cancer Read it here Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas. Nature genetics Read it here Toward understanding and exploiting tumor heterogeneity. Nature medicine Read it here Mutations leading to constitutive active gp130/JAK1/STAT3 pathway. Cytokine & growth factor reviews Read it here

Professional Associations HCC Summit, EASL, Geneva 2018 Co-organizer Cold Spring Harbor Asia liver metabolism and cancer, Suzhou (2016) Co-organizer Conférence européenne monothématique «Basic research in HCC» EASL, Geneva, 2014 Co-organizer Symposium « Liver tumors » à l’AACR, Washington, 2013, du FASEB liver Co-organizer

Honors Docteur Honoris Causa Université Catholique de Louvain Chevalier de la Légion d’honneur Prix René et André Duquesne Prix « Coups d’élan » Fondation Schueller-Bettencourt Prix Raymond Rosen, Fondation pour la Recherche Médicale Prix Charles Oberling Elected fellow of the European Academy of Cancer Sciences