Dr Julien Calderaro is board certified in Pathology and currently holds a position of Associate
Professor in the Pathology Department of Henri Mondor University Hospital in Créteil, France.
He is specialised in the field of liver diseases and tumors diagnosis.
His research is dedicated to the identification of the relationships between liver cancer
phenotype, genotype and immune microenvironment, with the aim of defining a robust
morphomolecular classification. He has also a particular interest in innovative image analysis
approaches, such as convolutional neural networks.
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Paris, France
French
/
English
Work Experience
Phd in INSERM U1162 « génomique fonctionnelle des tumeurs solides »(Pr Jessica Zucman- Rossi, Paris, France)Board Certified in Patholog
Since 2010
Education
Post Doctoral Fellowship
INSERM U1138 (Pr Sautès Fridman, Paris, France)
Resident in Pathology
2004 to 2010
Hopitaux de Paris
Pubmed
Development of AI-based pathology biomarkers in gastrointestinal and liver cancer.
2020
Nature reviews. Gastroenterology & hepatology
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B cells are associated with survival and immunotherapy response in sarcoma.
2020
Nature
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Detection of microsatellite instability in a panel of solid tumours with the Idylla MSI Test using extracted DNA.
Young Investigator Award, ILCA Conference, Vancouver,
2016
Recipient of Paul Mathieu Oncology Prize from the French Academy of Medicine
2016
Get updatedReceive the latest news from Prof. Julien Calderaro, Md, Phd
PubmedDevelopment of AI-based pathology biomarkers in gastrointestinal and liver cancer.
2020
Nature reviews. Gastroenterology & hepatology
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B cells are associated with survival and immunotherapy response in sarcoma.
2020
Nature
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Detection of microsatellite instability in a panel of solid tumours with the Idylla MSI Test using extracted DNA.
2020
Journal of clinical pathology
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Polyploidy spectrum: a new marker in HCC classification.
2020
Gut
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Adeno-associated virus in the liver: natural history and consequences in tumour development.
2020
Gut
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Intrahepatic immune changes after hepatitis c virus eradication by direct-acting antiviral therapy.
2020
Liver international : official journal of the International Association for the Study of the Liver
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BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA.
2020
Journal of hepatology
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Recurrent chromosomal rearrangements of <i>ROS1</i>, <i>FRK</i> and <i>IL6</i> activating JAK/STAT pathway in inflammatory hepatocellular adenomas.
2020
Gut
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Clinical Impact of Genomic Diversity From Early to Advanced Hepatocellular Carcinoma.
2020
Hepatology (Baltimore, Md.)
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Predicting survival after hepatocellular carcinoma resection using deep-learning on histological slides.
2020
Hepatology (Baltimore, Md.)
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Primary leiomyosarcoma of the liver: Two new cases and a systematic review.
2020
Annals of hepato-biliary-pancreatic surgery
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Multiphase Liver MRI for Identifying the Macrotrabecular-Massive Subtype of Hepatocellular Carcinoma.
2020
Radiology
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Early Hepatic Lesions Display Immature Tertiary Lymphoid Structures and Show Elevated Expression of Immune Inhibitory and Immunosuppressive Molecules.
2020
Clinical cancer research : an official journal of the American Association for Cancer Research
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Dual angiogenesis and PD-1 blockade in hepatocellular carcinoma.
2020
Hepatobiliary surgery and nutrition
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Corrigendum to: "BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA" [J Hepatol (2020) 1-13].
2020
Journal of hepatology
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BRAF-associated bile duct adenomatosis: a new entity?
2020
Histopathology
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Hepatobiliary MR contrast agent uptake as a predictive biomarker of aggressive features on pathology and reduced recurrence-free survival in resectable hepatocellular carcinoma: comparison with dual-tracer 18F-FDG and 18F-FCH PET/CT.
2020
European radiology
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Liver Resection for Solitary Transplantable Hepatocellular Carcinoma: The Role of AFP-Score.
2019
World journal of surgery
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Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma.
2019
Journal of hepatology
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PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases.
2019
International journal of cancer
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PD-L1 Expression and CD8<sup>+</sup> T-cell Infiltrate are Associated with Clinical Progression in Patients with Node-positive Prostate Cancer.
2019
European urology focus
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A 17-Beta-Hydroxysteroid Dehydrogenase 13 Variant Protects From Hepatocellular Carcinoma Development in Alcoholic Liver Disease.
2019
Hepatology (Baltimore, Md.)
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Iso- or hyperintensity of hepatocellular adenomas on hepatobiliary phase does not always correspond to hepatospecific contrast-agent uptake: importance for tumor subtyping.
2019
European radiology
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Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response.
2019
Gastroenterology
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<i>APC</i> germline hepatoblastomas demonstrate cisplatin-induced intratumor tertiary lymphoid structures.
2019
Oncoimmunology
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Tertiary lymphoid structures in the era of cancer immunotherapy.
2019
Nature reviews. Cancer
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Hepatocellular Carcinomas With Mutational Activation of Beta-Catenin Require Choline and Can Be Detected by Positron Emission Tomography.
2019
Gastroenterology
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Molecular and histological correlations in liver cancer.
2019
Journal of hepatology
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Small-Molecule Inhibitors of Cyclophilins Block Opening of the Mitochondrial Permeability Transition Pore and Protect Mice From Hepatic Ischemia/Reperfusion Injury.
2019
Gastroenterology
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ESM1 as a Marker of Macrotrabecular-Massive Hepatocellular Carcinoma.
2019
Clinical cancer research : an official journal of the American Association for Cancer Research
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Acute Biliary Obstruction after Transarterial Radioembolization with Yttrium-90.
2019
Journal of vascular and interventional radiology : JVIR
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Angiogenesis and immune checkpoint inhibitors as therapies for hepatocellular carcinoma: current knowledge and future research directions.
2019
Journal for immunotherapy of cancer
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Positron emission tomography/computed tomography with 18F-fluorocholine improve tumor staging and treatment allocation in patients with hepatocellular carcinoma.
2018
Journal of hepatology
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Hepatitis B Virus Pregenomic RNA in Hepatocellular Carcinoma: A Nosological and Prognostic Determinant.
2018
Hepatology (Baltimore, Md.)
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Differentiating focal nodular hyperplasia from hepatocellular adenoma: Is hepatobiliary phase MRI (HBP-MRI) using linear gadolinium chelates always useful?
2018
Abdominal radiology (New York)
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Correction to: Differentiating focal nodular hyperplasia from hepatocellular adenoma: Is hepatobiliary phase MRI (HBP-MRI) using linear gadolinium chelates always useful?
2018
Abdominal radiology (New York)
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Genomic perturbations reveal distinct regulatory networks in intrahepatic cholangiocarcinoma.
2018
Hepatology (Baltimore, Md.)
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Macrotrabecular-massive hepatocellular carcinoma: A distinctive histological subtype with clinical relevance.
2018
Hepatology (Baltimore, Md.)
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Interleukins-17 and 27 promote liver regeneration by sequentially inducing progenitor cell expansion and differentiation.
2018
Hepatology communications
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Curative salvage liver transplantation in patients with cirrhosis and hepatocellular carcinoma: An intention-to-treat analysis.
2018
Hepatology (Baltimore, Md.)
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AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation.
2018
Journal of hepatology
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Bevacizumab improves survival in patients with synchronous colorectal liver metastases provided the primary tumor is resected first.
2018
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
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Quantitative correlation between uptake of Gd-BOPTA on hepatobiliary phase and tumor molecular features in patients with benign hepatocellular lesions.
2018
European radiology
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Polycystic kidney features of the renal pathology in glycogen storage disease type I: possible evolution to renal neoplasia.
2018
Journal of inherited metabolic disease
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Hepatic Iron Overload following Liver Transplantation from a C282Y/H63D Compound Heterozygous Donor.
2018
Case reports in hepatology
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Dietary exacerbation of metabolic stress leads to accelerated hepatic carcinogenesis in glycogen storage disease type Ia.
2018
Journal of hepatology
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Systemic AA Amyloidosis Caused by Inflammatory Hepatocellular Adenoma.
2018
The New England journal of medicine
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Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress.
2018
Nature communications
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Argininosuccinate synthase 1 and periportal gene expression in sonic hedgehog hepatocellular adenomas.
2018
Hepatology (Baltimore, Md.)
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An Oxygenated and Transportable Machine Perfusion System Fully Rescues Liver Grafts Exposed to Lethal Ischemic Damage in a Pig Model of DCD Liver Transplantation.
2017
Transplantation
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Impact of hepatobiliary phase liver MRI versus Contrast-Enhanced Ultrasound after an inconclusive extracellular gadolinium-based contrast-enhanced MRI for the diagnosis of benign hepatocellular tumors.
2017
Abdominal radiology (New York)
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Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.
2017
Gastroenterology
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Germline and somatic DICER1 mutations in familial and sporadic liver tumors.
2017
Journal of hepatology
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Prediction of hepatocellular carcinoma recurrence after liver transplantation: Comparison of four explant-based prognostic models.
2017
Liver international : official journal of the International Association for the Study of the Liver
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Contribution of Ultra Deep Sequencing in the Clinical Diagnosis of a New Fungal Pathogen Species: <i>Basidiobolus meristosporus</i>.
2017
Frontiers in microbiology
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A phosphokinome-based screen uncovers new drug synergies for cancer driven by liver-specific gain of nononcogenic receptor tyrosine kinases.
2017
Hepatology (Baltimore, Md.)
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PD-L1 expression in perihilar and intrahepatic cholangiocarcinoma.
2017
Oncotarget
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Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification.
2017
Journal of hepatology
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Sorafenib vs surgical resection for hepatocellular carcinoma with macrovascular invasion: A propensity score analysis.
2017
Liver international : official journal of the International Association for the Study of the Liver
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Renal Medullary Carcinoma: Establishing Standards in Practice.
Hepatology (Baltimore, Md.)
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Impact of time to surgery in the outcome of patients with liver resection for BCLC 0-A stage hepatocellular carcinoma.
2017
Journal of hepatology
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Delayed and short course of rapamycin prevents organ rejection after allogeneic liver transplantation in rats.
Hepatology (Baltimore, Md.)
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Balanced Translocations Disrupting SMARCB1 Are Hallmark Recurrent Genetic Alterations in Renal Medullary Carcinomas.
2016
European urology
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Inflammatory hepatocellular adenomas developed in the setting of chronic liver disease and cirrhosis.
2016
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
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Minimally invasive surgery versus percutaneous radio frequency ablation for the treatment of single small (≤3 cm) hepatocellular carcinoma: a case-control study.
2016
Surgical endoscopy
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AAV2 and Hepatocellular Carcinoma.
2016
Human gene therapy
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An Unusual Cause of Cholecystitis.
2016
Gastroenterology
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Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV.
2016
Molecular therapy : the journal of the American Society of Gene Therapy
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Ultrasonography of gallbladder abnormalities due to schistosomiasis.
2016
Parasitology research
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Genotype-phenotype correlation of CTNNB1 mutations reveals different ß-catenin activity associated with liver tumor progression.
2016
Hepatology (Baltimore, Md.)
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Programmed death ligand 1 expression in hepatocellular carcinoma: Relationship With clinical and pathological features.
2016
Hepatology (Baltimore, Md.)
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Solitary splenic metastasis from nasopharyngeal carcinoma: a case report and systematic review of the literature.
2016
World journal of surgical oncology
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Primary Tumor Versus Liver-First Strategy in Patients with Stage IVA Colorectal Cancer: A Propensity Score Analysis of Long-term Outcomes and Recurrence Pattern.
2016
Annals of surgical oncology
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Role of Sorafenib in Patients With Recurrent Hepatocellular Carcinoma After Liver Transplantation.
2016
Progress in transplantation (Aliso Viejo, Calif.)
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Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.
2015
Nature genetics
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BRAF V600E mutations in bile duct adenomas.
2015
Hepatology (Baltimore, Md.)
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Integration of tumour and viral genomic characterizations in HBV-related hepatocellular carcinomas.
2015
Gut
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Differentiation of focal nodular hyperplasia from hepatocellular adenomas with low-mechanical-index contrast-enhanced sonography (CEUS): effect of size on diagnostic confidence.
2015
European radiology
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Bile duct adenoma should not be designated as a reactive process.
2015
Pathology international
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BRAF V600E mutational status in bile duct adenomas and hamartomas.
2015
Histopathology
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Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver.
2015
Oncotarget
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Differentiation of focal nodular hyperplasia from hepatocellular adenoma: Role of the quantitative analysis of gadobenate dimeglumine-enhanced hepatobiliary phase MRI.
2015
Journal of magnetic resonance imaging : JMRI
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Hepatectomy for hepatocellular carcinoma larger than 10 cm: preoperative risk stratification to prevent futile surgery.
2015
HPB : the official journal of the International Hepato Pancreato Biliary Association
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Hepatocellular nodules expressing markers of hepatocellular adenomas in Budd-Chiari syndrome and other rare hepatic vascular disorders.
2015
Journal of hepatology
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Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas.
2015
Nature genetics
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Young investigator challenge: Cytomorphologic analysis of cerebrospinal fluid in 70 pediatric patients with medulloblastoma and review of the literature focusing on novel diagnostic and prognostic tests.
2015
Cancer cytopathology
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Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis.
2014
Hepatology (Baltimore, Md.)
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Greening the work force in Brazilian hotels: the role of environmental training.
2014
Work (Reading, Mass.)
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Open and laparoscopic resection of hepatocellular adenoma: trends over 23 years at a specialist hepatobiliary unit.
2014
HPB : the official journal of the International Hepato Pancreato Biliary Association
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Imaging strategies before beginning treatment of colorectal liver metastases.
2014
Diagnostic and interventional imaging
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Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation.
2014
Cancer cell
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Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy.
2014
Kidney international
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Hepatocellular carcinoma and nodular regenerative hyperplasia after chemotherapy for metastatic colorectal carcinoma.
2014
Hepatology (Baltimore, Md.)
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ALDH3A1 is overexpressed in a subset of hepatocellular carcinoma characterised by activation of the Wnt/ß-catenin pathway.
2014
Virchows Archiv : an international journal of pathology
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PI3K/AKT pathway activation in bladder carcinogenesis.
2014
International journal of cancer
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Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma.