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Dr. Jean-Charles Nault, MD, PhD

Dr. Jean-Charles Nault, MD, PhD

Overview

Jean-Charles Nault received is a MD, PhD as a hepatologist. He is currently working in the

liver unit of the Bobigny Hospital in Bobigny, France with a high priority on early detection of

primary liver tumors and on therapeutic innovation together with the interventional

radiology unit directed by the Pr Olivier Seror. His research is dedicated to translational

research in particular the identification of new driver genes in hepatocellular adenoma and

hepatocellular carcinoma, of new therapeutic targets and of the molecular determinants of

hepatocellular carcinoma’s prognosis.
Paris Cedex, France
French / English

Work Experience

MCU PH
Since 2017
AP-HP, Assistance Publique - Hôpitaux de Paris
Chef de clinique assistant
Since 2013
APHP

Education

Habilitation à diriger des recherches
2017
Université Paris 13
MCU-PH depuis septembre
2017
Université Paris 13
Doctorat en Science, INSERM U1162/U1138 « génomique fonctionnelle des tumeurs solides »
2015
Dirigée par Pr Jessica Zucman-Rossi (Paris, France)
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Pubmed

Molecular perspectives for the treatment of hepatocellular carcinoma.
2020
Acta gastro-enterologica Belgica Read it here Recurrent chromosomal rearrangements of <i>ROS1</i>, <i>FRK</i> and <i>IL6</i> activating JAK/STAT pathway in inflammatory hepatocellular adenomas.
2020
Gut Read it here Transient elastography predicts survival after radiofrequency ablation of hepatocellular carcinoma developing on cirrhosis.
2020
Journal of gastroenterology and hepatology Read it here
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Professional Associations

Journal Of Hepatology Associate Editor (2018-actuellement) Editorial board de Gastroenterology Membre (2018-actuellement) Editorial board de Gut Membre (2019-actuellement)
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Education Habilitation à diriger des recherches
2017
Université Paris 13
MCU-PH depuis septembre
2017
Université Paris 13
Doctorat en Science, INSERM U1162/U1138 « génomique fonctionnelle des tumeurs solides »
2015
Dirigée par Pr Jessica Zucman-Rossi (Paris, France)
Diplôme Inter-Universitaire Centre d’Enseignement de la Statistique Appliquée à la Médecine et à la Biologie Médicale
2013
CESAM
Interne en hépato-gastroentérologie
2007 to 2012
Hôpitaux de Paris
Doctorat en médecine, spécialisation en Gastroentérologie et Hépatologie
2012
Université paris 5, Paris, France
Master 2 en Génétique
2009
Paris, France
Externat des hôpital
2000 to 2006
Faculté de médecine de Nice
Pubmed Molecular perspectives for the treatment of hepatocellular carcinoma.
2020
Acta gastro-enterologica Belgica Read it here Recurrent chromosomal rearrangements of <i>ROS1</i>, <i>FRK</i> and <i>IL6</i> activating JAK/STAT pathway in inflammatory hepatocellular adenomas.
2020
Gut Read it here Transient elastography predicts survival after radiofrequency ablation of hepatocellular carcinoma developing on cirrhosis.
2020
Journal of gastroenterology and hepatology Read it here Adeno-associated virus in the liver: natural history and consequences in tumour development.
2020
Gut Read it here Acute pericarditis: A rare complication of gastric variceal obturation with cyanoacrylate glue.
2020
Clinics and research in hepatology and gastroenterology Read it here TIPS for management of portal-hypertension-related complications in patients with cirrhosis.
2020
Clinics and research in hepatology and gastroenterology Read it here Hepatic haemangioendothelioma: A proteiform disease.
2020
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Read it here <i>RSPO2</i> abnormal transcripts result from read-through in liver tumours with high ß-catenin activation and <i>CTNNB1</i> mutations.
2020
Gut Read it here BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA.
2020
Journal of hepatology Read it here Clinical Impact of Genomic Diversity From Early to Advanced Hepatocellular Carcinoma.
2020
Hepatology (Baltimore, Md.) Read it here Milestones in the pathogenesis and management of primary liver cancer.
2020
Journal of hepatology Read it here Advances in molecular classification and precision oncology in hepatocellular carcinoma.
2020
Journal of hepatology Read it here The landscape of gene mutations in cirrhosis and hepatocellular carcinoma.
2020
Journal of hepatology Read it here Biomarkers for hepatobiliary cancers.
2020
Hepatology (Baltimore, Md.) Read it here Optimizing curative management of hepatocellular carcinoma.
2020
Liver international : official journal of the International Association for the Study of the Liver Read it here International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis.
2020
Liver international : official journal of the International Association for the Study of the Liver Read it here Corrigendum to: "BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA" [J Hepatol (2020) 1-13].
2020
Journal of hepatology Read it here Prior surveillance and antiviral treatment improve the prognosis of HCC developed in HBV patients in the West.
2020
Clinics and research in hepatology and gastroenterology Read it here PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases.
2019
International journal of cancer Read it here Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
2019
Annals of oncology : official journal of the European Society for Medical Oncology Read it here Cabozantinib and the moving field of systemic treatments in advanced hepatocellular carcinoma.
2019
Hepatobiliary surgery and nutrition Read it here A 17-Beta-Hydroxysteroid Dehydrogenase 13 Variant Protects From Hepatocellular Carcinoma Development in Alcoholic Liver Disease.
2019
Hepatology (Baltimore, Md.) Read it here Can We Move on From the Discussion of Direct Antiviral Agents and Risk of Hepatocellular Carcinoma Recurrence?
2019
Gastroenterology Read it here Mutational Processes in Hepatocellular Carcinoma: The Story of Aristolochic Acid.
2019
Seminars in liver disease Read it here Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response.
2019
Gastroenterology Read it here Genomic Medicine and Implications for Hepatocellular Carcinoma Prevention and Therapy.
2019
Gastroenterology Read it here ESM1 as a Marker of Macrotrabecular-Massive Hepatocellular Carcinoma.
2019
Clinical cancer research : an official journal of the American Association for Cancer Research Read it here Multibipolar Radiofrequency Ablation for the Treatment of Mass-Forming and Infiltrative Hepatocellular Carcinomas &gt; 5 cm: Long-Term Results.
2019
Liver cancer Read it here The role of telomeres and telomerase in cirrhosis and liver cancer.
2019
Nature reviews. Gastroenterology & hepatology Read it here Late onset of nivolumab-induced severe gastroduodenitis and cholangitis in a patient with stage IV melanoma.
2019
Immunotherapy Read it here Virologic control and severity of liver disease determine survival after radiofrequency ablation of hepatocellular carcinoma on cirrhosis.
2019
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Read it here Dynamic of systemic immunity and its impact on tumor recurrence after radiofrequency ablation of hepatocellular carcinoma.
2019
Oncoimmunology Read it here Natural history of liver adenomatosis: A long-term observational study.
2019
Journal of hepatology Read it here A Dive Into the Deep Heterogeneity of Hepatocellular Carcinoma.
2019
Gastroenterology Read it here The Linguistic Continuity of Ontario's Minority Francophone Population: Examining the Relationship between Culture and Linguistic Practices.
2019
Canadian review of sociology = Revue canadienne de sociologie Read it here Systemic Treatment for Advanced Hepatocellular Carcinoma.
2019
Liver cancer Read it here Correction to: "Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up".
2019
Annals of oncology : official journal of the European Society for Medical Oncology Read it here Percutaneous treatment of hepatocellular carcinoma: State of the art and innovations.
2018
Journal of hepatology Read it here Macrotrabecular-massive hepatocellular carcinoma: A distinctive histological subtype with clinical relevance.
2018
Hepatology (Baltimore, Md.) Read it here Positron emission tomography/computed tomography with 18F-fluorocholine improve tumor staging and treatment allocation in patients with hepatocellular carcinoma.
2018
Journal of hepatology Read it here Argininosuccinate synthase 1 and periportal gene expression in sonic hedgehog hepatocellular adenomas.
2018
Hepatology (Baltimore, Md.) Read it here Reply to: "Response to: Positron emission tomography/computed tomography with <sup>18</sup>F-fluorocholine improve tumor staging and treatment allocation in patients with hepatocellular carcinoma".
2018
Journal of hepatology Read it here The clinical implications of G1-G6 transcriptomic signature and 5-gene score in Korean patients with hepatocellular carcinoma.
2018
BMC cancer Read it here Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma.
2018
Gut Read it here Percutaneous ablation for HCC eligible to transplantation: providing more opportunities of remission in the context of graft shortage.
2018
Hepatobiliary surgery and nutrition Read it here Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
2018
Annals of oncology : official journal of the European Society for Medical Oncology Read it here Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
2018
Annals of oncology : official journal of the European Society for Medical Oncology Read it here Molecular classification of hepatocellular adenomas: impact on clinical practice.
2018
Hepatic oncology Read it here Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress.
2018
Nature communications Read it here Systemic AA Amyloidosis Caused by Inflammatory Hepatocellular Adenoma.
2018
The New England journal of medicine Read it here Benign liver tumors
2018
La Revue du praticien Read it here Constitutional and functional genetics of human alcohol-related hepatocellular carcinoma.
2017
Liver international : official journal of the International Association for the Study of the Liver Read it here Transarterial chemoembolization for early stage hepatocellular carcinoma decrease local tumor control and overall survival compared to radiofrequency ablation.
2017
Oncotarget Read it here Molecular targets for HCC and future treatments.
2017
Journal of hepatology Read it here The end of almost 10 years of negative RCTs in advanced hepatocellular carcinoma.
2017
Lancet (London, England) Read it here Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.
2017
Gastroenterology Read it here Germline and somatic DICER1 mutations in familial and sporadic liver tumors.
2017
Journal of hepatology Read it here Cancer Gene Discovery in Hepatocellular Carcinoma: The CRISPR/CAS9 Accelerator.
2017
Gastroenterology Read it here Proliferation Markers Are Associated with MET Expression in Hepatocellular Carcinoma and Predict Tivantinib Sensitivity <i>In Vitro</i>.
2017
Clinical cancer research : an official journal of the American Association for Cancer Research Read it here Autoimmune-like chronic hepatitis induced by olmesartan.
2017
Hepatology (Baltimore, Md.) Read it here Is "Segmentectomy" a Suitable Term to Use in Patients Undergoing Hepatic Segmental <sup>90</sup>Y Radioembolization for the Treatment of Hepatocellular Carcinoma Up to 3 cm?
2017
Radiology Read it here Advances in management of hepatocellular carcinoma.
2017
Current opinion in oncology Read it here Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification.
2017
Journal of hepatology Read it here Sorafenib vs surgical resection for hepatocellular carcinoma with macrovascular invasion: A propensity score analysis.
2017
Liver international : official journal of the International Association for the Study of the Liver Read it here Molecular classification of hepatocellular adenoma in clinical practice.
2017
Journal of hepatology Read it here Reply.
2017
Hepatology (Baltimore, Md.) Read it here Safety and Efficacy of Irreversible Electroporation for the Treatment of Hepatocellular Carcinoma Not Amenable to Thermal Ablation Techniques: A Retrospective Single-Center Case Series.
2017
Radiology Read it here AAV2 and Hepatocellular Carcinoma.
2016
Human gene therapy Read it here Pulmonary Consolidations due to Secondary Syphilis with Positive Bronchial Washing Immunohistochemistry.
2016
American journal of respiratory and critical care medicine Read it here The calm before the storm: a report from the International Liver Cancer Association Congress 2015 - part 2.
2016
Future oncology (London, England) Read it here The calm before the storm: a report from the International Liver Cancer Association Congress 2015--part 1.
2016
Future oncology (London, England) Read it here TERT promoter mutations in primary liver tumors.
2016
Clinics and research in hepatology and gastroenterology Read it here Percutaneous Treatment of Localized Infiltrative Hepatocellular Carcinoma Developing on Cirrhosis.
2016
Annals of surgical oncology Read it here Inflammatory hepatocellular adenomas developed in the setting of chronic liver disease and cirrhosis.
2016
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Read it here Prevalence and clinical significance of nodular regenerative hyperplasia in liver biopsies.
2016
Liver international : official journal of the International Association for the Study of the Liver Read it here Reply.
2016
Hepatology (Baltimore, Md.) Read it here Hepatocellular Carcinoma within Milan Criteria: No-Touch Multibipolar Radiofrequency Ablation for Treatment-Long-term Results.
2016
Radiology Read it here Role of the transjugular intrahepatic portosystemic shunt in the management of severe complications of portal hypertension in idiopathic noncirrhotic portal hypertension.
2016
Hepatology (Baltimore, Md.) Read it here Type 2 diabetes-associated hepatocellular carcinoma: A molecular profile.
2016
Clinical liver disease Read it here Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV.
2016
Molecular therapy : the journal of the American Society of Gene Therapy Read it here The transcriptomic G1-G6 signature of hepatocellular carcinoma in an Asian population: Association of G3 with microvascular invasion.
2016
Medicine Read it here A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.
2016
Nature medicine Read it here Adeno-associated virus type 2 as an oncogenic virus in human hepatocellular carcinoma.
2016
Molecular & cellular oncology Read it here The CRP level and STATE score predict survival in cirrhotic patients with hepatocellular carcinoma treated by transarterial embolization.
2016
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Read it here Hepatocellular carcinoma and direct acting antiviral treatments: Controversy after the revolution.
2016
Journal of hepatology Read it here Hepatocellular Carcinoma within Milan Criteria: No-Touch Multibipolar Radiofrequency Ablation for Treatment-Long-term Results.
2016
Radiology Read it here European experience of 573 liver resections for hepatocellular adenoma: a cross-sectional study by the AFC-HCA-2013 study group.
2016
HPB : the official journal of the International Hepato Pancreato Biliary Association Read it here Genetic profiling of hepatocellular carcinoma using next-generation sequencing.
2016
Journal of hepatology Read it here Stemness of liver cancer: From hepatitis B virus to Wnt activation.
2016
Journal of hepatology Read it here Genotype-phenotype correlation of CTNNB1 mutations reveals different ß-catenin activity associated with liver tumor progression.
2016
Hepatology (Baltimore, Md.) Read it here Reports from the International Liver Cancer Association (ILCA) congress 2014.
2015
Journal of hepatology Read it here Intratumor molecular and phenotypic diversity in hepatocellular carcinoma.
2015
Clinical cancer research : an official journal of the American Association for Cancer Research Read it here Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.
2015
Nature genetics Read it here Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas.
2015
Nature genetics Read it here NRF2/KEAP1 and Wnt/β-catenin in the multistep process of liver carcinogenesis in humans and rats.
2015
Hepatology (Baltimore, Md.) Read it here Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
2015
Gastroenterology Read it here Visceral fat area predicts survival in patients with advanced hepatocellular carcinoma treated with tyrosine kinase inhibitors.
2015
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Read it here Next generation sequencing, inter-tumor heterogeneity and prognosis of hepatitis B related hepatocellular carcinoma.
2014
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu Read it here Molecular profiling of liver tumors: classification and clinical translation for decision making.
2014
Seminars in liver disease Read it here
Professional Associations Journal Of Hepatology Associate Editor (2018-actuellement) Editorial board de Gastroenterology Membre (2018-actuellement) Editorial board de Gut Membre (2019-actuellement) Editorial board de Journal of Hepatology Membre ( 2014-2018) The European associations for the study of the liver (EASL) Membre International Liver Cancer Association (ILCA) Membre AFEF Membre Société Nationale Française de Gastroentérologie (SNFGE) Membre Comité scientifique de l’EMC hépatologie Membre « Young investigator » de l’European Association of the Study of the Liver Membre (EASL, 2018-2020) Comité de rédaction des guidelines de l’European Society for Medical Oncology (ESMO) sur la prise en charge du carcinome hépatocellulaire Membre 2018 ILCA (International Liver Cancer Association) Chair du communications commitee (2019-actuellement)

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