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Dr. Roberto Spreafico, MD, LMD

Overview

Dr. Roberto Spreafico received hsi DM Degree in 1982 from the University of Turin, Italy. He has done his Dental Studies at the University of Geneva where he got his DMD Degree in 1986. He is the Founder and Active Member of the Italian Academy of Esthetic Dentistry, the Founder of the Digital Dental Academy and of the International Academy for Digital Dental Medicine and an Active Member of several scientific societies.

He is Associate Editor of the International Journal of Esthetic Dentistry and Member of the editorial board of the Journal of Adhesive Dentistry.

Dr Spreafico presently conducts a number of courses in the field of esthetic dentistry throughout Italy and abroad.

 He is also author of numerous clinical papers on this topic.

 Author of 16 book chapters, he co-authored the book ” Adhesive Metal-Free Restorations : current concepts for the esthetic treatment of posterior teeth.” by Quintessence Publishing Group (1997).

His private practice is in Busto Arsizio, near Milano, Italy.
Busto Arsizio, Italy
Dental Surgery
Italian  /  English  /  French

Videos

Work Experience

Private Practice
Busto-Arsizio, Near Milano, Italy

Education

DMD Degree
1986
University of Geneva, School of Dentistry, Switzerland
DM
1982
University of Turin, Italy

Pubmed

Evidence-based concepts and procedures for bonded inlays and onlays. Part III. A case series with long-term clinical results and follow-up.
2019
The international journal of esthetic dentistry Read it here Sequential conditioning-stimulation reveals distinct gene- and stimulus-specific effects of Type I and II IFN on human macrophage functions.
2019
Scientific reports Read it here From Big Data to Precision Medicine.
2019
Frontiers in medicine Read it here
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Professional Associations

Accademia Italiana di Conservativa Active Member European Academy of Esthetic Dentistry (EAED). Active Member International Journal of Esthetic Dentistry (Berlin, Germany) Associate Editor
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Pubmed Evidence-based concepts and procedures for bonded inlays and onlays. Part III. A case series with long-term clinical results and follow-up.
2019
The international journal of esthetic dentistry Read it here Sequential conditioning-stimulation reveals distinct gene- and stimulus-specific effects of Type I and II IFN on human macrophage functions.
2019
Scientific reports Read it here From Big Data to Precision Medicine.
2019
Frontiers in medicine Read it here Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor.
2019
Proceedings of the National Academy of Sciences of the United States of America Read it here An image registration protocol to integrate electrophysiology, MRI and neuropathology data in epileptic patients explored with intracerebral electrodes.
2018
Journal of neuroscience methods Read it here ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues.
2018
Genome biology Read it here TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis.
2017
Annals of the rheumatic diseases Read it here The Syk-NFAT-IL-2 Pathway in Dendritic Cells Is Required for Optimal Sterile Immunity Elicited by Alum Adjuvants.
2017
Journal of immunology (Baltimore, Md. : 1950) Read it here FCD Type II and mTOR pathway: Evidence for different mechanisms involved in the pathogenesis of dysmorphic neurons.
2017
Epilepsy research Read it here Paleo-environmental record of polycyclic aromatic hydrocarbons and polychlorobiphenyls at the peripheral site GV7 in Victoria Land (East Antarctica).
2017
Chemosphere Read it here Iterative Modeling Reveals Evidence of Sequential Transcriptional Control Mechanisms.
2017
Cell systems Read it here Exhaustion-associated regulatory regions in CD8<sup>+</sup> tumor-infiltrating T cells.
2017
Proceedings of the National Academy of Sciences of the United States of America Read it here The histone variant H2A.Z promotes efficient cotranscriptional splicing in <i>S. cerevisiae</i>.
2017
Genes & development Read it here Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense.
2017
PLoS pathogens Read it here Seizure activity per se does not induce tissue damage markers in human neocortical focal epilepsy.
2017
Annals of neurology Read it here Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery.
2017
The New England journal of medicine Read it here Type II focal cortical dysplasia: Ex vivo 7T magnetic resonance imaging abnormalities and histopathological comparisons.
2016
Annals of neurology Read it here Short- and long-term surgical outcomes of temporal lobe epilepsy associated with hippocampal sclerosis: Relationships with neuropathology.
2016
Epilepsia Read it here Loss of the BBSome perturbs endocytic trafficking and disrupts virulence of Trypanosoma brucei.
2016
Proceedings of the National Academy of Sciences of the United States of America Read it here International recommendation for a comprehensive neuropathologic workup of epilepsy surgery brain tissue: A consensus Task Force report from the ILAE Commission on Diagnostic Methods.
2016
Epilepsia Read it here Antibody-Mediated Rejection in Lung Transplantation: Clinical Outcomes and Donor-Specific Antibody Characteristics.
2016
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Read it here Different parvalbumin and GABA expression in human epileptogenic focal cortical dysplasia.
2016
Epilepsia Read it here Epipolymorphisms associated with the clinical outcome of autoimmune arthritis affect CD4+ T cell activation pathways.
2016
Proceedings of the National Academy of Sciences of the United States of America Read it here Prolonged contact with dendritic cells turns lymph node-resident NK cells into anti-tumor effectors.
2016
EMBO molecular medicine Read it here Evaluation of the In Vitro Effects of Cervical Marginal Relocation Using Composite Resins on the Marginal Quality of CAD/CAM Crowns.
2016
The journal of adhesive dentistry Read it here Stereo-EEG, radiofrequency thermocoagulation and neuropathological correlations in a patient with MRI-negative type IIb focal cortical dysplasia.
2016
Seizure Read it here Increased autophagy in CD4<sup>+</sup> T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance.
2016
European journal of immunology Read it here Arterio-venous malformation of the mandible. Case report and review of literature.
2016
Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale Read it here Early cytokine signatures of ischemia/reperfusion injury in human orthotopic liver transplantation.
2016
JCI insight Read it here A circulating reservoir of pathogenic-like CD4+ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment.
2016
Annals of the rheumatic diseases Read it here Regulatory T-Cell Therapy in Transplantation and Severe Autoimmunity.
2015
Critical reviews in immunology Read it here Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.
2015
Journal of immunology (Baltimore, Md. : 1950) Read it here In vivo DTI tractography of the rat brain: an atlas of the main tracts in Paxinos space with histological comparison.
2015
Magnetic resonance imaging Read it here Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.
2015
Nature communications Read it here Evidence-based concepts and procedures for bonded inlays and onlays. Part I. Historical perspectives and clinical rationale for a biosubstitutive approach.
2015
The international journal of esthetic dentistry Read it here Training the 21st Century Immunologist.
2015
Trends in immunology Read it here Bitemporal epilepsy: A specific anatomo-electro-clinical phenotype in the temporal lobe epilepsy spectrum.
2015
Seizure Read it here Rapidly fatal late-onset status epilepticus due to occult bi-frontal cortical dysplasia. A case report.
2015
Journal of the neurological sciences Read it here Diagnostic methods and treatment options for focal cortical dysplasia.
2015
Epilepsia Read it here Assessment of human hippocampal developmental neuroanatomy by means of ex-vivo 7 T magnetic resonance imaging.
2014
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience Read it here Glyco-engineered anti-EGFR mAb elicits ADCC by NK cells from colorectal cancer patients irrespective of chemotherapy.
2014
British journal of cancer Read it here Early post-operative convulsive status epilepticus in a patient with drug-refractory temporal lobe epilepsy and type I focal cortical dysplasia.
2014
Seizure Read it here Long-term outcome after limited cortical resections in two cases of adult-onset Rasmussen encephalitis.
2014
Epilepsia Read it here Layer-specific gene expression in epileptogenic type II focal cortical dysplasia: normal-looking neurons reveal the presence of a hidden laminar organization.
2014
Acta neuropathologica communications Read it here Automatic classification of epilepsy types using ontology-based and genetics-based machine learning.
2014
Artificial intelligence in medicine Read it here Epilepsies associated with hippocampal sclerosis.
2014
Acta neuropathologica Read it here A sensitive protocol for FOXP3 epigenetic analysis in scarce human samples.
2014
European journal of immunology Read it here Optimization of rapid acquisition with relaxation enhancement (RARE) pulse sequence parameters for ¹⁹F-MRI studies.
2014
Journal of magnetic resonance imaging : JMRI Read it here An unusual behavioural and motor paroxysmal disorder caused by insulinoma-related hypoglycemia: a possible cause of epilepsy misdiagnosis.
2014
Seizure Read it here 7T MRI features in control human hippocampus and hippocampal sclerosis: an ex vivo study with histologic correlations.
2014
Epilepsia Read it here The international consensus classification for hippocampal sclerosis: an important step towards accurate prognosis.
2013
The Lancet. Neurology Read it here Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: a possible mechanism for therapeutic modulation of T cells.
2013
The Journal of allergy and clinical immunology Read it here Bilateral cavitations of ganglionic eminence: a fetal MR imaging sign of halted brain development.
2013
AJNR. American journal of neuroradiology Read it here Severe microcephaly with polynodular heterotopia: a high-field MRI and neuropathological case study.
2013
European journal of neurology Read it here International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods.
2013
Epilepsia Read it here Theory of mind and epilepsy: what clinical implications?
2013
Epilepsia Read it here Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release.
2013
Journal of immunology (Baltimore, Md. : 1950) Read it here Genesis of heterotopia in BCNU model of cortical dysplasia, detected by means of in utero electroporation.
2013
Developmental neuroscience Read it here Gold nanoparticles protected by fluorinated ligands for 19F MRI.
2013
Chemical communications (Cambridge, England) Read it here Human CD4+CD3- innate-like T cells provide a source of TNF and lymphotoxin-αβ and are elevated in rheumatoid arthritis.
2013
Journal of immunology (Baltimore, Md. : 1950) Read it here Overview of presurgical assessment and surgical treatment of epilepsy from the Italian League Against Epilepsy.
2013
Epilepsia Read it here Health Technology Assessment report on the presurgical evaluation and surgical treatment of drug-resistant epilepsy.
2013
Epilepsia Read it here Preoperative language lateralization in temporal lobe epilepsy (TLE) predicts peri-ictal, pre- and post-operative language performance: An fMRI study.
2013
NeuroImage. Clinical Read it here Identification of the Epileptogenic Zone from Stereo-EEG Signals: A Connectivity-Graph Theory Approach.
2013
Frontiers in neurology Read it here IL-15 cis presentation is required for optimal NK cell activation in lipopolysaccharide-mediated inflammatory conditions.
2013
Cell reports Read it here Malformations of cortical development.
2012
Brain pathology (Zurich, Switzerland) Read it here Sleep breathing disorders in 40 Italian patients with Myotonic dystrophy type 1.
2012
Neuromuscular disorders : NMD Read it here Similarities and differences of innate immune responses elicited by smooth and rough LPS.
2012
Immunology letters Read it here Epilepsy and NREM-parasomnia: a complex and reciprocal relationship.
2012
Sleep medicine Read it here Cause matters: a neuropathological challenge to human epilepsies.
2012
Brain pathology (Zurich, Switzerland) Read it here Good interobserver and intraobserver agreement in the evaluation of the new ILAE classification of focal cortical dysplasias.
2012
Epilepsia Read it here Epileptogenic networks of type II focal cortical dysplasia: a stereo-EEG study.
2012
NeuroImage Read it here Focal cortical dysplasia type IIa and IIb: MRI aspects in 118 cases proven by histopathology.
2012
Neuroradiology Read it here Blurring in patients with temporal lobe epilepsy: clinical, high-field imaging and ultrastructural study.
2012
Brain : a journal of neurology Read it here Cortical malformations.
2012
Handbook of clinical neurology Read it here Electroclinical, MRI and surgical outcomes in 100 epileptic patients with type II FCD.
2012
Epileptic disorders : international epilepsy journal with videotape Read it here Heterotopic reelin in human nodular heterotopia: a neuropathological study.
2012
Epileptic disorders : international epilepsy journal with videotape Read it here Expression of connexin 43 in the human epileptic and drug-resistant cerebral cortex.
2011
Neurology Read it here Aquaporin 4 expression in control and epileptic human cerebral cortex.
2011
Brain research Read it here Accuracy of pre-surgical fMRI confirmed by subsequent crossed aphasia.
2011
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Read it here An international consensus classification for focal cortical dysplasias.
2011
The Lancet. Neurology Read it here Development of cortical malformations in BCNU-treated rat, model of cortical dysplasia.
2011
Neuroscience Read it here The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission.
2011
Epilepsia Read it here Altered layer-specific gene expression in cortical samples from patients with temporal lobe epilepsy.
2011
Epilepsia Read it here Reelin and human nodular heterotopia.
2011
Epilepsia Read it here Combined 7-T MRI and histopathologic study of normal and dysplastic samples from patients with TLE.
2011
Neurology Read it here In vivo detection of cortical abnormalities in BCNU-treated rats, model of cortical dysplasia, using manganese-enhanced magnetic resonance imaging.
2011
Neuroscience Read it here Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors.
2011
Chemistry & biology Read it here Theory of mind in frontal and temporal lobe epilepsy: cognitive and neural aspects.
2011
Epilepsia Read it here Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18.
2011
Journal of immunology (Baltimore, Md. : 1950) Read it here Tractographic reconstruction protocol optimization in the rat brain in-vivo: towards a normal atlas.
2011
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference Read it here Partial Directed Coherence estimated on Stereo-EEG signals in patients with Taylor's type focal cortical dysplasia.
2010
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference Read it here Type I focal cortical dysplasia: surgical outcome is related to histopathology.
2010
Epileptic disorders : international epilepsy journal with videotape Read it here Focal Cortical Dysplasias: clinical implication of neuropathological classification systems.
2010
Acta neuropathologica Read it here Effect of diffusion-sensitizing gradient timings on the exponential, biexponential and diffusional kurtosis model parameters: in-vivo measurements in the rat thalamus.
2010
Magma (New York, N.Y.) Read it here Composite resin rehabilitation of eroded dentition in a bulimic patient: a case report.
2010
The European journal of esthetic dentistry : official journal of the European Academy of Esthetic Dentistry Read it here The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants.
2010
European journal of immunology Read it here Hemispherotomy and functional hemispherectomy: indications and outcome.
2010
Epilepsy research Read it here Temporal lobe epilepsy: neuropathological and clinical correlations in 243 surgically treated patients.
2009
Epileptic disorders : international epilepsy journal with videotape Read it here Malformations of cortical development and epilepsies: neuropathological findings with emphasis on focal cortical dysplasia.
2009
Epileptic disorders : international epilepsy journal with videotape Read it here
Professional Associations Accademia Italiana di Conservativa Active Member European Academy of Esthetic Dentistry (EAED). Active Member International Journal of Esthetic Dentistry (Berlin, Germany) Associate Editor Journal of Adhesive Dentistry Member of the Editorial Board Practical Procedures & Aesthetic Dentistry Member of the Commettee IAED, Italian Academy of Esthetic Dentistry Founder & Active Member Digital Dental Academy Founder International Academy for Digital Dental Medicine. Founder International Journal of Esthetic Dentistry (Berlin, Germany) Associate Editor

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