Prof. Markus Graefen, MD

Work Experience Professor of Urology Chief Physician Prostate Cancer Center Head of the Prostate Cancer Outpatient Clinic Senior Physician

Education Research assistant at the Department of Urology Habilitation - venia legendi for the subject urology DFG Scholar Board certification Research assistant at the Department of Urology General Surgery Degree Medical Degree

Pubmed Adherence to pelvic lymph node dissection recommendations according to the National Comprehensive Cancer Network pelvic lymph node dissection guideline and the D'Amico lymph node invasion risk stratification. Urologic oncology Read it here Deletion of 8p is an independent prognostic parameter in prostate cancer. Oncotarget Read it here Oncologic and Functional Outcomes after Radical Prostatectomy for High or Very High Risk Prostate Cancer: European Validation of the Current NCCN® Guideline. The Journal of urology Read it here Adjuvant and Salvage Radiotherapy after Radical Prostatectomy in Prostate Cancer Patients. European urology Read it here Radical prostatectomy neutralizes obesity-driven risk of prostate cancer progression. Urologic oncology Read it here Population-Based Validation of the 2014 ISUP Gleason Grade Groups in Patients Treated With Radical Prostatectomy, Brachytherapy, External Beam Radiation, or no Local Treatment. The Prostate Read it here High-Level γ-Glutamyl-Hydrolase (GGH) Expression is Linked to Poor Prognosis in ERG Negative Prostate Cancer. International journal of molecular sciences Read it here Correction: Genomic deletion of chromosome 12p is an independent prognostic marker in prostate cancer. Oncotarget Read it here Integrating Tertiary Gleason 5 Patterns into Quantitative Gleason Grading in Prostate Biopsies and Prostatectomy Specimens. European urology Read it here North American Population-Based Validation of the National Comprehensive Cancer Network Practice Guideline Recommendation of Pelvic Lymphadenectomy in Contemporary Prostate Cancer. The Prostate Read it here Prognostic value of the new Grade Groups in Prostate Cancer: a multi-institutional European validation study. Prostate cancer and prostatic diseases Read it here Ten-year experience of robot-assisted radical prostatectomy: the road from cherry-picking to standard procedure. Minerva urologica e nefrologica = The Italian journal of urology and nephrology Read it here [Phase II study with metastatic castration-resistant prostate cancer (mCRPC) patients]. Der Urologe. Ausg. A Read it here Functional Outcomes and Quality of Life After Radical Prostatectomy Only Versus a Combination of Prostatectomy with Radiation and Hormonal Therapy. European urology Read it here Effect of repeat prostate biopsies on functional outcomes after radical prostatectomy. Urologic oncology Read it here Low-risk Prostate Cancer: Identification, Management, and Outcomes. European urology Read it here Up-regulation of mismatch repair genes MSH6, PMS2 and MLH1 parallels development of genetic instability and is linked to tumor aggressiveness and early PSA recurrence in prostate cancer. Carcinogenesis Read it here Comorbidity and age cannot explain variation in life expectancy associated with treatment of non-metastatic prostate cancer. World journal of urology Read it here High Chance of Late Recovery of Urinary and Erectile Function Beyond 12 Months After Radical Prostatectomy. European urology Read it here Adjuvant radiation therapy is associated with better oncological outcome compared with salvage radiation therapy in patients with pN1 prostate cancer treated with radical prostatectomy. BJU international Read it here Use of adjuvant chemotherapy in radical cystectomy patients aged >65 years: a population-based study from the surveillance epidemiology and end results (SEER)-medicare database. Minerva urologica e nefrologica = The Italian journal of urology and nephrology Read it here Population-Based External Validation of the Updated 2012 Partin Tables in Contemporary North American Prostate Cancer Patients. The Prostate Read it here The Impact of Repeat Prostate Biopsies on Oncologic, Pathological and Perioperative Outcomes after Radical Prostatectomy. The Journal of urology Read it here Differences in Patient Characteristics among Men Choosing Open or Robot-Assisted Radical Prostatectomy in Contemporary Practice - Analysis of Surveillance, Epidemiology, and End Results Database. Urologia internationalis Read it here Primary Gleason pattern upgrading in contemporary patients with D'Amico low-risk prostate cancer: implications for future biomarkers and imaging modalities. BJU international Read it here A proposal of a new nomogram for predicting upstaging in contemporary D'Amico low-risk prostate cancer patients. World journal of urology Read it here Tumor volume improves the long-term prediction of biochemical recurrence-free survival after radical prostatectomy for localized prostate cancer with positive surgical margins. World journal of urology Read it here Association between Lymph Node Counts and Oncological Outcomes in Lymph Node Positive Prostate Cancer. European urology focus Read it here High concordance of findings obtained from transgluteal magnetic resonance imaging - and transrectal ultrasonography-guided biopsy as compared with prostatectomy specimens. BJU international Read it here [Phase III study for local or locally advanced prostate cancer : Randomized, double-blind, placebo-controlled phase 3 study of apalutamide in patients with local high-risk prostate cancer or locally advanced prostate cancer receiving primary radiotherapy (ATLAS) - study AP 90/15 of the AUO]. Der Urologe. Ausg. A Read it here Long-term survival of patients aged 80 years or older treated with radical prostatectomy for prostate cancer. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Read it here Long-term oncological outcomes in patients with limited nodal disease undergoing radical prostatectomy and pelvic lymph node dissection without adjuvant treatment. World journal of urology Read it here Radical prostatectomy or radiotherapy reduce prostate cancer mortality in elderly patients: a population-based propensity score adjusted analysis. World journal of urology Read it here FOXA1 expression is a strong independent predictor of early PSA recurrence in ERG negative prostate cancers treated by radical prostatectomy. Carcinogenesis Read it here Summary statement on screening for prostate cancer in Europe. International journal of cancer Read it here Are the Results of the Prostate Testing for Cancer and Treatment Trial Applicable to Contemporary Prostate Cancer Patients Treated with Radical Prostatectomy? Results from Two High-volume European Institutions. European urology focus Read it here Clinical Case Discussion: Primary Treatment for Prostate Cancer in an Elderly Man-Treatment of the Primary Tumor is Necessary. European urology focus Read it here [Radical prostatectomy in locally advanced prostate cancer]. Der Urologe. Ausg. A Read it here [Phase II study of pembrolizumab (MK-3475) in patients with metastatic castration-resistant prostate cancer (KEYNOTE-199)-study AP 93/16 of the AUO]. Der Urologe. Ausg. A Read it here Comparison of 11 Active Surveillance Protocols in Contemporary European Men Treated With Radical Prostatectomy. Clinical genitourinary cancer Read it here Local Therapy Improves Survival in Metastatic Prostate Cancer. European urology Read it here High-Level Glyoxalase 1 (GLO1) expression is linked to poor prognosis in prostate cancer. The Prostate Read it here Short- and Long-term Functional Outcomes and Quality of Life after Radical Prostatectomy: Patient-reported Outcomes from a Tertiary High-volume Center. European urology focus Read it here Up-regulation of Biglycan is Associated with Poor Prognosis and PTEN Deletion in Patients with Prostate Cancer. Neoplasia (New York, N.Y.) Read it here Assessment of Oncological Outcomes After Radical Prostatectomy According to Preoperative and Postoperative Cancer of the Prostate Risk Assessment Scores: Results from a Large, Two-center Experience. European urology focus Read it here First North American validation and head-to-head comparison of four preoperative nomograms for prediction of lymph node invasion before radical prostatectomy. BJU international Read it here Radical prostatectomy in oligometastatic prostate cancer. Current opinion in urology Read it here Trends in Radical Prostatectomy Risk Group Distribution in a European Multicenter Analysis of 28 572 Patients: Towards Tailored Treatment. European urology focus Read it here Survival Among Men at High Risk of Disseminated Prostate Cancer Receiving Initial Locally Directed Radical Treatment or Initial Androgen Deprivation Therapy. European urology Read it here Impact of preoperative risk on metastatic progression and cancer-specific mortality in patients with adverse pathology at radical prostatectomy. BJU international Read it here Income and health-related quality of life among prostate cancer patients over a one-year period after radical prostatectomy: a linear mixed model analysis. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation Read it here Defining biochemical recurrence after radical prostatectomy and timing of early salvage radiotherapy : Informing the debate. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] Read it here The survival impact of neoadjuvant hormonal therapy before radical prostatectomy for treatment of high-risk prostate cancer. Prostate cancer and prostatic diseases Read it here External Beam Radiotherapy Affects Serum Testosterone in Patients With Localized Prostate Cancer. The journal of sexual medicine Read it here Reply to Paolo Capogrosso, Francesco Montorsi, and Andrea Salonia's Letter to the Editor re: Philipp Mandel, Felix Preisser, Markus Graefen, et al. High Chance of Late Recovery of Urinary and Erectile Function Beyond 12 Months After Radical Prostatectomy. Eur Urol 2017;71:848-50. Late Recovery of Erectile Function After Radical Prostatectomy: Should We Modify the Way of Assessment? European urology Read it here The EMPaCT Classifier: A Validated Tool to Predict Postoperative Prostate Cancer-related Death Using Competing-risk Analysis. European urology focus Read it here Incidence, Risk Factors, Management, and Complications of Rectal Injuries During Radical Prostatectomy. European urology focus Read it here Survival Outcomes in Octogenarian and Nonagenarian Patients Treated with First-line Androgen Deprivation Therapy for Organ-confined Prostate Cancer. European urology focus Read it here Does Cytoreductive Prostatectomy Really Have an Impact on Prognosis in Prostate Cancer Patients with Low-volume Bone Metastasis? Results from a Prospective Case-Control Study. European urology focus Read it here A Critical Analysis of the Current Knowledge of Surgical Anatomy of the Prostate Related to Optimisation of Cancer Control and Preservation of Continence and Erection in Candidates for Radical Prostatectomy: An Update. European urology Read it here Differences in Patient Characteristics Among Men Choosing Open or Robot-Assisted Radical Prostatectomy in Contemporary Practice at a European High-Volume Center. Urologia internationalis Read it here Cytoplasmic accumulation of ELAVL1 is an independent predictor of biochemical recurrence associated with genomic instability in prostate cancer. The Prostate Read it here The Combination of DNA Ploidy Status and PTEN/6q15 Deletions Provides Strong and Independent Prognostic Information in Prostate Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research Read it here Oncological, functional and perioperative outcomes in transplant patients after radical prostatectomy. World journal of urology Read it here Prognostic Significance of Incidental Prostate Cancer at Radical Cystoprostatectomy for Bladder Cancer. Urologia internationalis Read it here Tumor Characteristics and Oncologic Outcome after Radical Prostatectomy in Men 75 Years Old or Older. The Journal of urology Read it here Additional elastography-targeted biopsy improves the agreement between biopsy Gleason grade and Gleason grade at radical prostatectomy. World journal of urology Read it here Very long-term survival patterns of young patients treated with radical prostatectomy for high-risk prostate cancer. Urologic oncology Read it here Aquaporin 5 expression is frequent in prostate cancer and shows a dichotomous correlation with tumor phenotype and PSA recurrence. Human pathology Read it here Five-year biochemical recurrence-free and overall survival following high-dose-rate brachytherapy with additional external beam or radical prostatectomy in patients with clinically localized prostate cancer. Urologic oncology Read it here Clinical Utility of Quantitative Gleason Grading in Prostate Biopsies and Prostatectomy Specimens. European urology Read it here Detailed Quantification of High-grade Cancer Allows Precise Prediction of Prostate Cancer Prognosis. European urology Read it here When Should a Positive Surgical Margin Ring a Bell? An Analysis of a Multi-Institutional Robot-Assisted Laparoscopic Radical Prostatectomy Database. Journal of endourology Read it here Reduced AZGP1 expression is an independent predictor of early PSA recurrence and associated with ERG-fusion positive and PTEN deleted prostate cancers. International journal of cancer Read it here Prostate cancer patients' quality of life assessments across the primary treatment trajectory: 'True' change or response shift? Acta oncologica (Stockholm, Sweden) Read it here Intermediate-term cancer control outcomes in prostate cancer patients treated with robotic-assisted laparoscopic radical prostatectomy: a multi-institutional analysis. World journal of urology Read it here Deletion of 18q is a strong and independent prognostic feature in prostate cancer. Oncotarget Read it here Older patients with low Charlson score and high-risk prostate cancer benefit from radical prostatectomy. World journal of urology Read it here Suboptimal use of neoadjuvant chemotherapy in radical cystectomy patients: A population-based study. Canadian Urological Association journal = Journal de l'Association des urologues du Canada Read it here Impact of Lymph Node Burden on Survival of High-risk Prostate Cancer Patients Following Radical Prostatectomy and Pelvic Lymph Node Dissection. Frontiers in surgery Read it here Suboptimal use of pelvic lymph node dissection: Differences in guideline adherence between robot-assisted and open radical prostatectomy. Canadian Urological Association journal = Journal de l'Association des urologues du Canada Read it here p16 upregulation is linked to poor prognosis in ERG negative prostate cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Read it here [PROKOMB - prostate-cooperative MRI project Berlin-study AP 95/16 of the AUO]. Der Urologe. Ausg. A Read it here Impact of perioperative administration of 6 % hydroxyethyl starch 130/0.4 on serum cystatin C-derived renal function after radical prostatectomy: a single-centre retrospective study. BMC anesthesiology Read it here Low Other Cause Mortality Rates Reflect Good Patient Selection in Patients with Prostate Cancer Treated with Radical Prostatectomy. The Journal of urology Read it here Heterogeneity of ERG expression in prostate cancer: a large section mapping study of entire prostatectomy specimens from 125 patients. BMC cancer Read it here [Social Inequality in Utilization of Aftercare Services Among Breast and Prostate Cancer Patients]. Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) Read it here Socioeconomic status and health-related quality of life among patients with prostate cancer 6 months after radical prostatectomy: a longitudinal analysis. BMJ open Read it here Clinical performance of prostate health index in men with tPSA>10ng/ml: Results from a multicentric European study. Urologic oncology Read it here Impact of surgeon-defined capsular incision during radical prostatectomy on biochemical recurrence rates. World journal of urology Read it here Posterior musculofascial reconstruction after radical prostatectomy: an updated systematic review and a meta-analysis. BJU international Read it here Medical management of benign prostatic hyperplasia: Results from a population-based study. Canadian Urological Association journal = Journal de l'Association des urologues du Canada Read it here The Role of Pelvic Lymph Node Dissection During Radical Prostatectomy in Patients With Gleason 6 Intermediate-risk Prostate Cancer. Urology Read it here Assessment of the Rate of Adherence to International Guidelines for Androgen Deprivation Therapy with External-beam Radiation Therapy: A Population-based Study. European urology Read it here [Systematic analysis of treatment results as a quality control instrument using the example of a large European center]. Der Urologe. Ausg. A Read it here Overexpression of enhancer of zeste homolog 2 (EZH2) characterizes an aggressive subset of prostate cancers and predicts patient prognosis independently from pre- and postoperatively assessed clinicopathological parameters. Carcinogenesis Read it here ["Expanded prostate cancer index composite" (EPIC-26): Results of functional treatment in patients with localized prostate cancer]. Der Urologe. Ausg. A Read it here Adjuvant Radiotherapy in Prostate Cancer Patients Treated with Surgery: The Impact of Age and Tumor Characteristics. European urology focus Read it here Comparison of Two Prostate Cancer Risk Calculators that Include the Prostate Health Index. European urology focus Read it here

Professional Associations European Association of Urology (EAU) Member American Urology Association (AUA) Member German Society of Urology Member European Urologic Robotic Section Member of the Board Working Group Urological Oncology Board member European Guidelines Commission Member German S3 Guidelines Commission Member European Urology Editorial Board Member

Honors Peter Bischoff Prize North German Society of Urology Peter Bischoff Prize North German Society of Urology Peter Bischoff Prize North German Society of Urology Peter Bischoff Prize North German Society of Urology Peter Bischoff Prize North German Society of Urology Peter Bischoff Prize North German Society of Urology GE Konjetzny Prize Hamburg Cancer Society